Median Percent Changes in BMD and Total Body Fat by Body Region Over Time¹

Weeks

Percent Change in Spine Total BMD (%) Median (IQR)

Percent Change in Left Hip BMD (%) Median (IQR)

Percent Change in Trunk Body Fat (%) Median (IQR)

Percent Change in Limb Total Body Fat (%) Median (IQR)

0 - 48

0.29 (−1.8 - 2.1)

−1.25 (−2.5- 0.2)

−0.82 (−5.8 - 15.2)

2.12 (−4.8 - 15.8)

0 - 96

−0.11 (−2.6 - 2.1)

−1.75 (−2.5 - 0.2)

−3.04 (−37.3 - 10.9)

2.01 (−13.9 - 21.1)

Median Changes in BMD (grams/cm²) and Total Body Fat (grams) by Body Region Over Time¹

Time

Spine Total BMD Median (IQR)

Left Hip BMD Median (IQR)

Trunk Body Fat Trunk Body Fat

Limb Total Body Fat Median (IQR)

Baseline/Day 1

1.29 (1.17 - 1.39)

1.09 (0.99 - 1.16)

15421.00 (10556.0 - 20180.0)

8413.00 (6643.0 - 12184.0)

Week 48

1.31 (1.15-1.36)

1.10 (1.00 - 1.15)

17214.00 (8288.00 - 23285.0)

8591.00 (6241.0 - 13819.0)

Week 96

1.31 (1.17-1.34)

1.09 (0.98 - 1.17)

12413.50 (6619.0 - 19996..0)

8477.00 (6154.0 - 9098.0)